Cellular-level connections provide potential targets for improved diagnosis and treatment
HUNTSVILLE, Ala. -- Sleeping, eating, working; humans, as well as many other living organisms, have circadian patterns, regularly occurring, 24-hour rhythms, that are part of normal function. Dysfunctions in regular patterns – such as insomnia and unexplained fluctuations in appetite, body temperature and/or hormones — are symptoms shared by many patients with depression. Researchers at the HudsonAlpha Institute for Biotechnology, with scientists at the University of Michigan, the University of California at Irvine, Stanford University and Weill Cornell Medical College, collaborated in a study where they found the first direct evidence connecting cellular level activity in the brains of patients with depression to out-of-step circadian rhythms. These groups have been part of the Pritzker Neuropsychiatric Disorders Research Consortium for the past decade.